Total Synthesis and Immunosuppressive Activity of (−)-Pateamine A and Related Compounds:  Implementation of a β-Lactam-Based Macrocyclization

The asymmetric synthesis of the potent immunosuppressive agent (−)-pateamine A isolated from the marine sponge Mycale sp. is described. A key strategy employed in the synthesis was a β-lactam-based macrocyclization to form the 19-membered dilactone macrolide. The synthesis confirms the relative and...

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Veröffentlicht in:	Journal of the American Chemical Society 1998-12, Vol.120 (47), p.12237-12254
Hauptverfasser:	Romo, Daniel, Rzasa, Robert M, Shea, Helene A, Park, Kaapjoo, Langenhan, Joseph M, Sun, Luo, Akhiezer, Alexander, Liu, Jun O
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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