Unusually Strong Dependence of Conformation on Solvent

Relative partition coefficients between aqueous methanol and pentane of the two stereoisomers of a series of 4-tert-butylcyclohexylamines were measured by NMR. The cis isomer shows a larger partition coefficient, with a ΔΔG°org → aq up to 1.4 kcal/mol. A thermodynamic cycle relates these values to a...

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Veröffentlicht in:	Journal of the American Chemical Society 1998-02, Vol.120 (5), p.1044-1047
Hauptverfasser:	Perrin, Charles L, Fabian, Miles A, Rivero, Ignacio A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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