Interplay of Hydrogen Abstraction and Radical Repair in the Generation of Single- and Double-Strand DNA Damage by the Esperamicins

The source of hydrogens for the quenching of the phenylene diradical produced by esperamicin A (espA) and by esperamicin C (espC) in the presence of specifically deuteriated, double-stranded DNA (dsDNA) has been determined. Remarkably, both espA and espC were quenched at both positions of the diphen...

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Veröffentlicht in:	Journal of the American Chemical Society 1997-07, Vol.119 (29), p.6731-6738
Hauptverfasser:	Epstein, Jessica L, Zhang, Xiaodong, Doss, George A, Liesch, Jerrold M, Krishnan, Bala, Stubbe, Kozarich, John W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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