Biomimetic Synthesis of Resorcylate Natural Products Utilizing Late Stage Aromatization: Concise Total Syntheses of the Marine Antifungal Agents 15G256ι and 15G256β

Diketo-1,3-dioxin-2-ones underwent retro-Diels−Alder reaction on heating in toluene at 110 °C to generate α,γ,ϵ-triketo-ketenes. These were trapped with alcohols to provide 2,4,6-triketocarboxylates, which were smoothly aromatized by sequential reaction with potassium carbonate and methanolic hydrog...

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Veröffentlicht in:	Journal of the American Chemical Society 2008-08, Vol.130 (31), p.10293-10298
Hauptverfasser:	Navarro, Ismael, Basset, Jean-François, Hebbe, Séverine, Major, Sarah M, Werner, Thomas, Howsham, Catherine, Bräckow, Jan, Barrett, Anthony G. M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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