Total Synthesis and Complete Structural Assignment of Yaku’amide A

Here we report the first total synthesis and the complete stereochemical assignment of yaku’amide A. Yaku’amide A (1) was isolated from a sponge Ceratopsion sp. as an extremely potent cytotoxin. Its structure was determined except for the C4-stereochemistry in the N-terminal acyl group (NTA). This t...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2013-04, Vol.135 (14), p.5467-5474
Hauptverfasser:	Kuranaga, Takefumi, Sesoko, Yusuke, Sakata, Komei, Maeda, Naoya, Hayata, Atsushi, Inoue, Masayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Molecular Structure Oligopeptides - chemical synthesis Oligopeptides - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!