Alkynyl Phosphonate DNA: A Versatile “Click”able Backbone for DNA-Based Biological Applications

Major hurdles associated with DNA-based biological applications include, among others, targeted cell delivery, undesirable nonspecific effects, toxicity associated with various analogues or the reagents used to deliver oligonucleotides to cells, and stability toward intracellular enzymes. Although a...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of the American Chemical Society 2012-07, Vol.134 (28), p.11618-11631
Hauptverfasser:	Krishna, Heera, Caruthers, Marvin H
Format:	Artikel
Sprache:	eng
Schlagworte:	DNA - chemistry Organophosphonates - chemistry Solid-Phase Synthesis Techniques
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!