Depurinating Acylfulvene−DNA Adducts: Characterizing Cellular Chemical Reactions of a Selective Antitumor Agent

Acylfulvenes (AFs) are a class of semisynthetic agents with high toxicity toward certain tumor cells, and for one analogue, hydroxymethylacylfulvene (HMAF), clinical trials are in progress. DNA alkylation by AFs, mediated by bioreductive activation, is believed to contribute to cytotoxicity, but the...

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Veröffentlicht in:	Journal of the American Chemical Society 2007-02, Vol.129 (7), p.2101-2111
Hauptverfasser:	Gong, Jiachang, Vaidyanathan, V. G, Yu, Xiang, Kensler, Thomas W, Peterson, Lisa A, Sturla, Shana J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alcohol Oxidoreductases - chemistry Alcohol Oxidoreductases - metabolism Alkylation Animals Antineoplastic Agents, Alkylating - chemistry Antineoplastic Agents, Alkylating - pharmacology Cattle Cells, Cultured Chromatography, High Pressure Liquid Deoxyadenosines - chemistry Deoxyadenosines - metabolism Deoxyguanosine - chemistry Deoxyguanosine - metabolism DNA - chemistry DNA - drug effects DNA - metabolism DNA Adducts - chemistry DNA Adducts - metabolism Humans NADP - chemistry NADP - metabolism Nucleic Acid Conformation Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Spectrometry, Mass, Electrospray Ionization Spiro Compounds - chemistry Spiro Compounds - pharmacology
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