A Strain-Promoted [3 + 2] Azide−Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems

Selective chemical reactions that are orthogonal to the diverse functionality of biological systems have become important tools in the field of chemical biology. Two notable examples are the Staudinger ligation of azides and phosphines and the Cu(I)-catalyzed [3 + 2] cycloaddition of azides and alky...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-11, Vol.126 (46), p.15046-15047
Hauptverfasser:	Agard, Nicholas J, Prescher, Jennifer A, Bertozzi, Carolyn R
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Alkynes - metabolism Animals Azides - chemistry Azides - metabolism Biological and medical sciences Biotin - chemistry Biotin - metabolism CHO Cells Cricetinae Cyclization Cyclooctanes - chemistry Cyclooctanes - metabolism Fundamental and applied biological sciences. Psychology Glycoproteins - chemistry Glycoproteins - metabolism Humans Jurkat Cells Mechanisms. Catalysis. Electron transfer. Models Molecular biophysics Physical chemistry in biology
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