Design and Synthesis of an Expanded Porphyrin That Has Selectivity for the c-MYC G-Quadruplex Structure

Cationic porphyrins are known to bind to and stabilize different types of G-quadruplexes. Recent studies have shown the biological relevance of the intramolecular parallel G-quadruplex as a transcriptional silencer in the c-MYC promoter. TMPyP4 also binds to this G-quadruplex and most likely convert...

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Veröffentlicht in:	Journal of the American Chemical Society 2005-03, Vol.127 (9), p.2944-2959
Hauptverfasser:	Seenisamy, Jeyaprakashnarayanan, Bashyam, Sridevi, Gokhale, Vijay, Vankayalapati, Hariprasad, Sun, Daekyu, Siddiqui-Jain, Adam, Streiner, Nicole, Shin-ya, Kazuo, White, Elizabeth, Wilson, W. David, Hurley, Laurence H
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding, Competitive Biological and medical sciences DNA - chemistry DNA - genetics DNA - metabolism DNA, Single-Stranded - chemistry DNA, Single-Stranded - metabolism Fundamental and applied biological sciences. Psychology G-Quadruplexes Genes, myc Guanine - metabolism HeLa Cells Humans Interactions. Associations Intermolecular phenomena Models, Molecular Molecular biophysics Nucleic Acid Conformation - drug effects Oxazoles - chemistry Oxazoles - metabolism Oxazoles - pharmacology Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - metabolism Porphyrins - pharmacology Promoter Regions, Genetic Selenium Compounds - chemical synthesis Selenium Compounds - chemistry Selenium Compounds - metabolism Selenium Compounds - pharmacology Substrate Specificity Surface Plasmon Resonance Telomere - chemistry Telomere - metabolism
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