Biosynthetic Origins of the Natural Product, Thiolactomycin: A Unique and Selective Inhibitor of Type II Dissociated Fatty Acid Synthases

Thiolactomycin (TLM), a natural product produced by both Nocardia and Streptomyces spp., is a potent and highly selective inhibitor of the type II dissociated fatty acid synthases of plants and bacteria. The unique mode of action of TLM and its low toxicity make it an attractive compound for develop...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-08, Vol.125 (34), p.10166-10167
Hauptverfasser:	Brown, Maria S, Akopiants, Konstantin, Resceck, Diane M, McArthur, Hamish A. I, McCormick, Ellen, Reynolds, Kevin A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetyltransferases - antagonists & inhibitors Acetyltransferases - metabolism Anti-Bacterial Agents - biosynthesis Anti-Bacterial Agents - chemical synthesis Chemistry Enzyme Inhibitors - chemical synthesis Exact sciences and technology Fatty Acid Synthase, Type II Fermentation Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Multienzyme Complexes - antagonists & inhibitors Multienzyme Complexes - metabolism Nocardia - metabolism Organic chemistry Preparations and properties Thiophenes - chemical synthesis Thiophenes - metabolism
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