Efficient RNase H-Directed Cleavage of RNA Promoted by Antisense DNA or 2‘F-ANA Constructs Containing Acyclic Nucleotide Inserts

The ability of modified antisense oligonucleotides (AONs) containing acyclic interresidue units to support RNase H-promoted cleavage of complementary RNA is described. Manipulation of the backbone and sugar geometries in these conformationally labile monomers shows great benefits in the enzymatic re...

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Veröffentlicht in:	Journal of the American Chemical Society 2003-01, Vol.125 (3), p.654-661
Hauptverfasser:	Mangos, Maria M, Min, Kyung-Lyum, Viazovkina, Ekaterina, Galarneau, Annie, Elzagheid, Mohamed I, Parniak, Michael A, Damha, Masad J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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