Synthesis of Monoglucosylated High-Mannose-Type Dodecasaccharide, a Putative Ligand for Molecular Chaperone, Calnexin, and Calreticurin
Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was ob...
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| Veröffentlicht in: | Journal of the American Chemical Society 2003-03, Vol.125 (12), p.3402-3403 |
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| container_end_page | 3403 |
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| container_issue | 12 |
| container_start_page | 3402 |
| container_title | Journal of the American Chemical Society |
| container_volume | 125 |
| creator | Matsuo, Ichiro Wada, Megumi Manabe, Shino Yamaguchi, Yoshiki Otake, Keisuke Kato, Koichi Ito, Yukishige |
| description | Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained. |
| doi_str_mv | 10.1021/ja021288q |
| format | Article |
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Am. Chem. Soc</addtitle><date>2003-03-26</date><risdate>2003</risdate><volume>125</volume><issue>12</issue><spage>3402</spage><epage>3403</epage><pages>3402-3403</pages><issn>0002-7863</issn><eissn>1520-5126</eissn><coden>JACSAT</coden><abstract>Convergent and stereoselective synthetic routes to Man9GlcNAc2 (1b), α-Glc1M9GlcNAc2 (2b), and its stereoisomer β-Glc1M9GlcNAc2 (3) were established. Interaction analysis of 2b with CRT was measured by 1H NMR spectroscopy, and the first NMR-based evidence for the specific binding of CRT to 2b was obtained.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><doi>10.1021/ja021288q</doi><tpages>2</tpages></addata></record> |
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| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2003-03, Vol.125 (12), p.3402-3403 |
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| language | eng |
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| source | American Chemical Society Journals |
| subjects | Carbohydrates with 4, 5, 6, ... C atoms, dissacharides and oligosaccharides Carbohydrates. Nucleosides and nucleotides Chemistry Exact sciences and technology Organic chemistry Preparations and properties |
| title | Synthesis of Monoglucosylated High-Mannose-Type Dodecasaccharide, a Putative Ligand for Molecular Chaperone, Calnexin, and Calreticurin |
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