Model-Free Approach to the Dynamic Interpretation of Residual Dipolar Couplings in Globular Proteins

The effects of internal motions on residual dipolar NMR couplings of proteins partially aligned in a liquid-crystalline environment are analyzed using a 10 ns molecular dynamics (MD) computer simulation of ubiquitin. For a set of alignment tensors with different orientations and rhombicities, MD-ave...

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Veröffentlicht in:	Journal of the American Chemical Society 2001-06, Vol.123 (25), p.6098-6107
Hauptverfasser:	Meiler, Jens, Prompers, Jeanine J, Peti, Wolfgang, Griesinger, Christian, Brüschweiler, Rafael
Format:	Artikel
Sprache:	eng
Schlagworte:	Computer Simulation Electrochemistry Kinetics Nuclear Magnetic Resonance, Biomolecular Protein Conformation Proteins - chemistry Ubiquitins - chemistry
Online-Zugang:	Volltext
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