Development of a Small-Scale Automated Solubility Measurement Apparatus

Development of a Small-Scale Automated Solubility Measurement Apparatus

A semiautomated device for solubility measurements in solution volumes as low as 1 mL was developed for pharmaceutical applications. The device operates nonisothermally, and can measure multiple samples simultaneously. Solubilities of model compounds such as paracetamol, mannitol, adipic acid, and g...

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Veröffentlicht in:Industrial & engineering chemistry research 2005-07, Vol.44 (15), p.5427-5433
Hauptverfasser: Yi, Yongjin, Hatziavramidis, Dimitri, Myerson, Allan S, Waldo, Michael, Beylin, Vladimir G, Mustakis, Jason
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Applied sciences
Chemical engineering
Exact sciences and technology
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container_end_page 5433
container_issue 15
container_start_page 5427
container_title Industrial & engineering chemistry research
container_volume 44
creator Yi, Yongjin
Hatziavramidis, Dimitri
Myerson, Allan S
Waldo, Michael
Beylin, Vladimir G
Mustakis, Jason
description A semiautomated device for solubility measurements in solution volumes as low as 1 mL was developed for pharmaceutical applications. The device operates nonisothermally, and can measure multiple samples simultaneously. Solubilities of model compounds such as paracetamol, mannitol, adipic acid, and glycine were measured and showed a maximum deviation of 5 wt % compared to literature data. Extrapolation of solubility data in the form of activity coefficients was found in good agreement with the literature value over a wide range of temperatures for paracetamol in 2-propanol and adipic acid in ethanol, while some deviation was observed for mannitol in water. The use of the solubility-measuring device to perform solvent screening on multiple solvents for early-stage pharmaceutical compounds was also examined. Results indicate that the slope of the solubility curve with temperature can be estimated with limited data for multiple solvents.
doi_str_mv 10.1021/ie049215y
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Exact sciences and technology
title Development of a Small-Scale Automated Solubility Measurement Apparatus
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