Effects of Crystal Form on Solubility and Pharmacokinetics: A Crystal Engineering Case Study of Lamotrigine

In this contribution, we describe how the supramolecular synthon approach can be used for discovery of novel crystal forms and for enhancing the relevant preclinical properties of a low solubility antiepileptic drug, lamotrigine (6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine). Ten novel crystal...

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Veröffentlicht in:	Crystal growth & design 2010-01, Vol.10 (1), p.394-405
Hauptverfasser:	Cheney, Miranda L, Shan, Ning, Healey, Elisabeth R, Hanna, Mazen, Wojtas, Lukasz, Zaworotko, Michael J, Sava, Vasyl, Song, Shijie, Sanchez-Ramos, Juan R
Format:	Artikel
Sprache:	eng
Schlagworte:	Condensed matter: structure, mechanical and thermal properties Cross-disciplinary physics: materials science rheology Equations of state, phase equilibria, and phase transitions Exact sciences and technology Materials science Methods of crystal growth physics of crystal growth Organic compounds Physics Solubility, segregation, and mixing phase separation Structure of solids and liquids crystallography Structure of specific crystalline solids
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