A Twist in Cocrystals of Salts: Changes in Packing and Chloride Coordination Lead to Opposite Trends in the Biopharmaceutical Performance of Fluoroquinolone Hydrochloride Cocrystals

Fluoroquinolones are extensively used antibiotics that are generally prescribed as hydrochloride salts because the neutral forms display low solubility due to their zwitterionic character. Starting from the hydrochloride salts of ciprofloxacin (CiHCl) or (S,S)-moxifloxacin (MoHCl) and 4-hydroxybenzo...

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Veröffentlicht in:	Crystal growth & design 2014-06, Vol.14 (6), p.3078-3095
Hauptverfasser:	Martínez-Alejo, Juan M, Domínguez-Chávez, Jorge G, Rivera-Islas, Jesús, Herrera-Ruiz, Dea, Höpfl, Herbert, Morales-Rojas, Hugo, Senosiain, Juan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Condensed matter: structure, mechanical and thermal properties Constant-composition solid-solid phase transformations: polymorphic, massive, and order-disorder Cross-disciplinary physics: materials science rheology Equations of state, phase equilibria, and phase transitions Exact sciences and technology Materials science Phase diagrams and microstructures developed by solidification and solid-solid phase transformations Physics Solid-solid transitions Solubility, segregation, and mixing phase separation Specific phase transitions Thermal expansion thermomechanical effects and density Thermal properties of condensed matter Thermal properties of crystalline solids
Online-Zugang:	Volltext
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