Understanding the Formation of Indomethacin–Saccharin Cocrystals by Anti-Solvent Crystallization

Pharmaceutical cocrystals are a novel drug form with the potential to enhance pharmaceutical properties, including the solubility and dissolution behavior for BCS class II drug substances such as indomethacin (IMC). Recently, we reported that pure indomethacin–saccharin (IMC–SAC) cocrystals were pre...

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Veröffentlicht in:	Crystal growth & design 2013-05, Vol.13 (5), p.2067-2074
Hauptverfasser:	Lee, Min-Jeong, Chun, Nan-Hee, Wang, In-Chun, Liu, J. Jay, Jeong, Myung-Yung, Choi, Guang J
Format:	Artikel
Sprache:	eng
Schlagworte:	Condensed matter: structure, mechanical and thermal properties Cross-disciplinary physics: materials science rheology Equations of state, phase equilibria, and phase transitions Exact sciences and technology Materials science Methods of crystal growth physics of crystal growth Phase diagrams and microstructures developed by solidification and solid-solid phase transformations Phase diagrams of metals and alloys Physics Solid-solid transitions Solubility, segregation, and mixing phase separation Specific phase transitions
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