Polymorphism of Dehydro-Aripiprazole, the Active Metabolite of the Antipsychotic Drug Aripiprazole (Abilify)

Crystal form exploration of dehydro-aripiprazole (dAPZ), the active metabolite of the antipsychotic drug aripiprazole (APZ), elucidated five polymorphs (I, II, III, IV, and V), two methanol solvates, and a monohydrate. The forms were characterized by thermal microscopy, differential scanning calorim...

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Veröffentlicht in:	Crystal growth & design 2013-05, Vol.13 (5), p.2036-2046
Hauptverfasser:	Zeidan, Tarek A, Trotta, Jacob T, Chiarella, Renato A, Oliveira, Mark A, Hickey, Magali B, Almarsson, Örn, Remenar, Julius F
Format:	Artikel
Sprache:	eng
Schlagworte:	Condensed matter: structure, mechanical and thermal properties Crystalline state (including molecular motions in solids) Crystallographic aspects of phase transformations pressure effects Exact sciences and technology Physics Structure of solids and liquids crystallography Structure of specific crystalline solids
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