Platelet Responses to Compound Interactions with Thrombin

Catalytic and noncatalytic interactions of thrombin with platelets are investigated with use of thrombin variants with altered specificities and with ligands of thrombin receptors on platelets. Both α-thrombin and weakly coagulant meizothrombin-des-fragment-1 (μ-thrombin) hydrolyze proteolytically a...

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Veröffentlicht in:	Biochemistry (Easton) 1999-07, Vol.38 (28), p.8936-8947
Hauptverfasser:	Smith, Reginald D, Owen, Whyte G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - secretion Amino Acid Chloromethyl Ketones - pharmacology Animals Antithrombins - pharmacology Blood Platelets - drug effects Blood Platelets - metabolism Blood Platelets - secretion Catalysis Cattle Cells, Cultured Drug Synergism Enzyme Precursors - pharmacology Humans Immunoglobulins - pharmacology Peptide Fragments - chemistry Peptide Fragments - genetics Platelet Activation - drug effects Receptor, PAR-1 Receptors, Thrombin - chemistry Receptors, Thrombin - genetics Receptors, Thrombin - immunology Recombinant Proteins - chemistry Recombinant Proteins - immunology Substrate Specificity - genetics Swine Thrombin - antagonists & inhibitors Thrombin - metabolism Thrombin - pharmacology
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