Delineation of Two Functionally Distinct γPDE Binding Sites on the Bovine Retinal cGMP Phosphodiesterase by a Mutant γPDE Subunit

The γ subunit of the retinal cGMP phosphodiesterase (γPDE) acts as an inhibitor of phosphodiesterase (PDE) catalytic activity and mediates enzyme regulation by the α subunit of the GTP-binding protein transducin (αT). In this work, we describe a full length, doubly point-mutated γ subunit, C68S, Y84...

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Veröffentlicht in:	Biochemistry (Easton) 1999-01, Vol.38 (4), p.1293-1299
Hauptverfasser:	Berger, Allan L, Cerione, Richard A, Erickson, Jon W
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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