Specific and Reversible Inactivation of Protein Tyrosine Phosphatases by Hydrogen Peroxide: Evidence for a Sulfenic Acid Intermediate and Implications for Redox Regulation

Protein tyrosine phosphatases (PTPs) catalyze the hydrolysis of phosphotyrosine from specific signal-transducing proteins. Although regulatory mechanisms for protein kinases have been described, no general mechanism for controlling PTPs has been demonstrated. Numerous reports have shown that cellula...

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Veröffentlicht in:	Biochemistry (Easton) 1998-04, Vol.37 (16), p.5633-5642
Hauptverfasser:	Denu, John M, Tanner, Kirk G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites - drug effects Catalysis Cysteine - metabolism Dual Specificity Phosphatase 3 Enzyme Activation - drug effects Humans Hydrogen Peroxide - pharmacology Intracellular Signaling Peptides and Proteins Leukocytes - enzymology Nerve Tissue Proteins - antagonists & inhibitors Oxidation-Reduction PC12 Cells Phosphoprotein Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatase, Non-Receptor Type 6 Protein Tyrosine Phosphatases - antagonists & inhibitors Protein Tyrosine Phosphatases - metabolism Rats Receptor-Like Protein Tyrosine Phosphatases, Class 7 Sulfenic Acids - metabolism Vaccinia virus - enzymology
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