Examination of the Transition State of the Low-Molecular Mass Small Tyrosine Phosphatase 1. Comparisons with Other Protein Phosphatases

The reactions of p-nitrophenyl phosphate (pNPP) with the low-molecular mass tyrosine phosphatase Stp1 and with the mutants D128N, D128A, D128E, and S18A have been studied by measurement of heavy-atom isotope effects in the substrate. The isotope effects were measured at the nonbridging oxygen atoms...

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Veröffentlicht in:Biochemistry (Easton) 1997-06, Vol.36 (25), p.7928-7936
Hauptverfasser: Hengge, Alvan C, Zhao, Yu, Wu, Li, Zhang, Zhong-Yin
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Sprache:eng
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