A Naturally Occurring Protective System in Urea-Rich Cells:  Mechanism of Osmolyte Protection of Proteins against Urea Denaturation

Trimethylamine N-oxide (TMAO) is a solute concentrated in the urea-rich cells of elasmobranchs and coelacanth to offset the damaging effects of urea on intracellular protein structure and function. On the basis of transfer free energy measurements, favorable interaction of TMAO with amino acid side...

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Veröffentlicht in:	Biochemistry (Easton) 1997-07, Vol.36 (30), p.9101-9108
Hauptverfasser:	Wang, Aijun, Bolen, D. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - metabolism Animals Diketopiperazines Elasmobranchii - metabolism Methylamines - metabolism Oxidants - metabolism Piperazines - metabolism Protein Conformation Protein Denaturation - drug effects Solubility Temperature Thermodynamics Urea - metabolism Urea - pharmacology Water-Electrolyte Balance
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