Three-Dimensional Structure of the α-Conotoxin GI at 1.2 Å Resolution

Predatory marine snails of the genus Conus paralyze their fish prey by injecting a potent toxin. The α-conotoxin GI is a 13-residue peptide isolated from venom of Conus geographus. It functions by blocking the postsynaptic nicotinic acetylcholine receptor. After crystallization in deionized water, t...

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Veröffentlicht in:	Biochemistry (Easton) 1996-09, Vol.35 (35), p.11329-11335
Hauptverfasser:	Guddat, L. W, Martin, J. A, Shan, L, Edmundson, A. B, Gray, W. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Conotoxins Crystallography, X-Ray Disulfides - chemistry Hydrogen Bonding Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Mollusk Venoms - chemistry Nicotinic Antagonists - chemistry Nicotinic Antagonists - pharmacology Peptides - chemical synthesis Peptides - chemistry Peptides, Cyclic - chemistry Protein Conformation Protein Structure, Secondary Protein Structure, Tertiary Snails Water - metabolism
Online-Zugang:	Volltext
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