Substrate Specificity Determinants of the Methanogen Homoaconitase Enzyme: Structure and Function of the Small Subunit

The aconitase family of hydro-lyase enzymes includes three classes of proteins that catalyze the isomerization of α-hydroxy acids to β-hydroxy acids. Besides aconitase, isopropylmalate isomerase (IPMI) proteins specifically catalyze the isomerization of α,β-dicarboxylates with hydrophobic γ-chain gr...

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Veröffentlicht in:	Biochemistry (Easton) 2010-03, Vol.49 (12), p.2687-2696
Hauptverfasser:	Jeyakanthan, Jeyaraman, Drevland, Randy M, Gayathri, Dasara Raju, Velmurugan, Devadasan, Shinkai, Akeo, Kuramitsu, Seiki, Yokoyama, Shigeyuki, Graham, David E
Format:	Artikel
Sprache:	eng
Schlagworte:	Aconitate Hydratase - chemistry Amino Acid Substitution Archaeal Proteins - chemistry Base Sequence Binding Sites - genetics Catalysis Euryarchaeota - enzymology Euryarchaeota - metabolism Evolution, Molecular Hydro-Lyases - chemistry Hydro-Lyases - genetics Isomerases - chemistry Kinetics Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed - methods Protein Conformation Protein Subunits Sequence Alignment Structure-Activity Relationship Substrate Specificity - genetics
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