Active Site Mapping of MraY, a Member of the Polyprenyl-phosphate N-Acetylhexosamine 1-Phosphate Transferase Superfamily, Catalyzing the First Membrane Step of Peptidoglycan Biosynthesis

The MraY transferase is an integral membrane protein that catalyzes an essential step of peptidoglycan biosynthesis, namely the transfer of the phospho-N-acetylmuramoyl-pentapeptide motif onto the undecaprenyl phosphate carrier lipid. It belongs to a large superfamily of eukaryotic and prokaryotic p...

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Veröffentlicht in:	Biochemistry (Easton) 2008-08, Vol.47 (34), p.8919-8928
Hauptverfasser:	Al-Dabbagh, Bayan, Henry, Xavier, Ghachi, Meriem El, Auger, Geneviève, Blanot, Didier, Parquet, Claudine, Mengin-Lecreulx, Dominique, Bouhss, Ahmed
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacillus subtilis - enzymology Bacillus subtilis - genetics Bacillus subtilis - metabolism Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Binding Sites Enzyme Activation - drug effects Genetic Complementation Test Hydrogen-Ion Concentration Magnesium Chloride - pharmacology Models, Biological Molecular Sequence Data Mutagenesis, Site-Directed Mutation Peptidoglycan - biosynthesis Transferases (Other Substituted Phosphate Groups) - chemistry Transferases (Other Substituted Phosphate Groups) - genetics Transferases (Other Substituted Phosphate Groups) - metabolism Transferases - chemistry Transferases - genetics Transferases - metabolism Transformation, Genetic
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