Engineering the Glucansucrase GTFR Enzyme Reaction and Glycosidic Bond Specificity: Toward Tailor-Made Polymer and Oligosaccharide Products

Two long-standing questions about glucansucrases (EC 2.4.1.5) are how they control oligosaccharide versus polysaccharide synthesis and how they direct their glycosidic linkage specificity. This information is required for the production of tailor-made saccharides. Mutagenesis promises to be an effec...

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Veröffentlicht in:	Biochemistry (Easton) 2008-06, Vol.47 (25), p.6678-6684
Hauptverfasser:	Hellmuth, Hendrik, Wittrock, Sabine, Kralj, Slavko, Dijkhuizen, Lubbert, Hofer, Bernd, Seibel, Jürgen
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Carbohydrate Sequence Chromatography, Thin Layer Enzyme Assays Glucans - chemistry Glucans - metabolism Glucosyltransferases - chemistry Glucosyltransferases - genetics Glucosyltransferases - metabolism Glycosides - chemistry Glycosides - metabolism Glycosylation Glycosyltransferases - chemistry Glycosyltransferases - genetics Glycosyltransferases - metabolism Hydrolysis Kinetics Molecular Sequence Data Molecular Structure Mutation Oligosaccharides - chemistry Oligosaccharides - metabolism Polymers - chemistry Polymers - metabolism Protein Engineering Streptococcus oralis - enzymology Streptococcus oralis - genetics Substrate Specificity
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