Peroxisome Proliferation-Activated Receptor δ Agonist GW0742 Interacts Weakly with Multiple Nuclear Receptors, Including the Vitamin D Receptor

A high-throughput screening campaign was conducted to identify small molecules with the ability to inhibit the interaction between the vitamin D receptor (VDR) and steroid receptor coactivator 2. These inhibitors represent novel molecular probes for modulating gene regulation mediated by VDR. Peroxi...

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Veröffentlicht in:	Biochemistry (Easton) 2013-06, Vol.52 (24), p.4193-4203
Hauptverfasser:	Nandhikonda, Premchendar, Yasgar, Adam, Baranowski, Athena M, Sidhu, Preetpal S, McCallum, Megan M, Pawlak, Alan J, Teske, Kelly, Feleke, Belaynesh, Yuan, Nina Y, Kevin, Chinedum, Bikle, Daniel D, Ayers, Steven D, Webb, Paul, Rai, Ganesha, Simeonov, Anton, Jadhav, Ajit, Maloney, David, Arnold, Leggy A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Nucleus - metabolism DNA - chemistry Dose-Response Relationship, Drug HEK293 Cells HL-60 Cells Humans Inhibitory Concentration 50 Ligands Nuclear Receptor Coactivator 2 - chemistry PPAR delta - agonists Protein Binding Receptors, Calcitriol - chemistry Rhodamines - chemistry Spectrophotometry - methods Thiazoles - pharmacology
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