Assembly and Signaling of CRLR and RAMP1 Complexes Assessed by BRET

Biochemical and functional evidence suggest that the calcitonin receptor-like receptor (CRLR) interacts with receptor activity-modifying protein-1 (RAMP1) to generate a calcitonin gene-related peptide (CGRP) receptor. Using bioluminescence resonance energy transfer (BRET), we investigated the oligom...

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Veröffentlicht in:	Biochemistry (Easton) 2007-06, Vol.46 (23), p.7022-7033
Hauptverfasser:	Héroux, Madeleine, Breton, Billy, Hogue, Mireille, Bouvier, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcitonin Gene-Related Peptide - chemistry Calcitonin Gene-Related Peptide - metabolism Calcitonin Receptor-Like Protein Cell Line Cell Membrane - metabolism Humans Kidney Luciferases - metabolism Mutagenesis, Site-Directed Polymerase Chain Reaction Radioligand Assay Receptors, Calcitonin - chemistry Receptors, Calcitonin - genetics Receptors, Calcitonin - metabolism Receptors, Calcitonin Gene-Related Peptide - metabolism Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - metabolism Renilla - enzymology Sequence Deletion Signal Transduction Transfection
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