Molecular Characterization of Human Melanocortin-3 Receptor Ligand−Receptor Interaction

Melanocortin-3 receptor (MC3R), primarily expressed in the hypothalamus, plays an important role in the regulation of energy homeostasis. MC3R-deficient (MC3R -/-) mice demonstrate increased fat mass, higher feeding efficiency, hyperleptinaemia, and mild hyperinsulinism. At least one specific mutati...

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Veröffentlicht in:	Biochemistry (Easton) 2006-01, Vol.45 (4), p.1128-1137
Hauptverfasser:	Chen, Min, Aprahamian, Charles J, Celik, Ahmet, Georgeson, Keith E, Garvey, W. Timothy, Harmon, Carroll M, Yang, Yingkui
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-MSH - analogs & derivatives alpha-MSH - chemistry alpha-MSH - metabolism Amino Acid Sequence Amino Acid Substitution - genetics Amino Acid Substitution - physiology Amino Acids, Aromatic - genetics Amino Acids, Aromatic - metabolism Humans Kinetics Ligands Melanocyte-Stimulating Hormones - metabolism Melanocyte-Stimulating Hormones - pharmacology Membrane Proteins - metabolism Models, Biological Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Protein Binding - genetics Protein Binding - physiology Protein Structure, Tertiary - genetics Receptor, Melanocortin, Type 3 - antagonists & inhibitors Receptor, Melanocortin, Type 3 - chemistry Receptor, Melanocortin, Type 3 - genetics Receptor, Melanocortin, Type 3 - metabolism Receptors, Peptide - metabolism Signal Transduction Transfection
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