Identification of Coagulation Factor VIII A2 Domain Residues Forming the Binding Epitope for Low-Density Lipoprotein Receptor-Related Protein

Regulation of the coagulation factor VIII (fVIII) level in circulation involves a hepatic receptor low-density lipoprotein receptor-related protein (LRP). One of two major LRP binding sites in fVIII is located within the A2 domain (A2), likely exposed within the fVIII complex with von Willebrand fac...

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Veröffentlicht in:	Biochemistry (Easton) 2006-02, Vol.45 (6), p.1829-1840
Hauptverfasser:	Sarafanov, Andrey G, Makogonenko, Evgeny M, Pechik, Igor V, Radtke, Klaus-Peter, Khrenov, Alexey V, Ananyeva, Natalya M, Strickland, Dudley K, Saenko, Evgueni L
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Animals Baculoviridae - genetics Baculoviridae - metabolism Base Sequence Binding Sites Cell Membrane - metabolism Cells, Cultured Epitopes - genetics Epitopes - metabolism Factor VIII - chemistry Factor VIII - genetics Factor VIII - isolation & purification Factor VIII - metabolism Half-Life LDL-Receptor Related Protein-Associated Protein - metabolism Liver - metabolism Mice Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed Receptors, Immunologic - metabolism Surface Plasmon Resonance
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