Prevention of MKK6-Dependent Activation by Binding to p38α MAP Kinase

Inhibition of p38α MAP kinase is a potential approach for the treatment of inflammatory disorders. MKK6-dependent phosphorylation on the activation loop of p38α increases its catalytic activity and affinity for ATP. An inhibitor, BIRB796, binds at a site used by the purine moiety of ATP and extends...

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Veröffentlicht in:	Biochemistry (Easton) 2005-12, Vol.44 (50), p.16475-16490
Hauptverfasser:	Sullivan, Jane E, Holdgate, Geoffrey A, Campbell, Douglas, Timms, David, Gerhardt, Stefan, Breed, Jason, Breeze, Alexander L, Bermingham, Alun, Pauptit, Richard A, Norman, Richard A, Embrey, Kevin J, Read, Jon, VanScyoc, Wendy S, Ward, Walter H. J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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