Isomers of Epidermal Growth Factor with Ser ⇒ Cys Mutation at the N-Terminal Sequence:  Isomerization, Stability, Unfolding, Refolding, and Structure

The structure of human epidermal growth factor (EGF, 53 amino acids) comprises three distinct loops (A, B, and C) connected correspondingly by the three native disulfide bonds, Cys6−Cys20, Cys14−Cys31, and Cys33−Cys42. The connection of Cys6 and Cys20 forming the N-terminal A loop is essential for t...

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