Acylation of Lysine 860 Allows Tight Binding and Cytotoxicity of Bordetella Adenylate Cyclase on CD11b-Expressing Cells

The Bordetella adenylate cyclase toxin-hemolysin (CyaA, ACT, or AC-Hly) forms cation-selective membrane channels and delivers into the cytosol of target cells an adenylate cyclase domain (AC) that catalyzes uncontrolled conversion of cellular ATP to cAMP. Both toxin activities were previously shown...

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Veröffentlicht in:	Biochemistry (Easton) 2005-09, Vol.44 (38), p.12759-12766
Hauptverfasser:	Masin, Jiri, Basler, Marek, Knapp, Oliver, El-Azami-El-Idrissi, Mohammed, Maier, Elke, Konopasek, Ivo, Benz, Roland, Leclerc, Claude, Sebo, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	Acylation Adenylate Cyclase Toxin - chemistry Adenylate Cyclase Toxin - toxicity Animals Binding, Competitive Cations CD11b Antigen - metabolism Cell Line Cricetinae Erythrocytes - drug effects Ion Channels - chemistry Ion Channels - metabolism Lysine - chemistry Macrophages - drug effects Mice Protein Binding
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