Secondary Structure Formation of a Transmembrane Segment in Kv Channels

Transmembrane segments in the intact voltage-gated potassium (Kv) channel are helical. To ascertain whether this helicity could first be manifested inside the ribosomal tunnel, we generated biogenic peptide intermediates of Kv1.3 and mass-tagged the cysteine-scanned S6 transmembrane segment using pe...

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Veröffentlicht in:	Biochemistry (Easton) 2005-06, Vol.44 (23), p.8230-8243
Hauptverfasser:	Lu, Jianli, Deutsch, Carol
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Calmodulin - chemistry Endoplasmic Reticulum - chemistry Endoplasmic Reticulum - genetics Endoplasmic Reticulum - metabolism Intracellular Membranes - chemistry Intracellular Membranes - metabolism Kv1.3 Potassium Channel Maleimides - chemistry Membrane Proteins - chemistry Membrane Proteins - genetics Molecular Sequence Data Mutagenesis, Site-Directed Peptide Fragments - chemistry Peptide Fragments - genetics Polyethylene Glycols - chemistry Potassium Channels, Voltage-Gated - chemistry Potassium Channels, Voltage-Gated - genetics Protein Folding Protein Processing, Post-Translational - genetics Protein Structure, Secondary - genetics Ribosomal Proteins - chemistry Ribosomal Proteins - genetics
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