Catalytic Mechanism of Guanidinoacetate Methyltransferase: Crystal Structures of Guanidinoacetate Methyltransferase Ternary Complexes

Guanidinoacetate methyltransferase (GAMT) is the enzyme that catalyzes the last step of creatine biosynthesis. The enzyme is found in abundance in the livers of all vertebrates. The intact GAMT from recombinant rat liver has been crystallized with an inhibitor S-adenosylhomocysteine (SAH) and a subs...

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Veröffentlicht in:	Biochemistry (Easton) 2004-11, Vol.43 (45), p.14385-14394
Hauptverfasser:	Komoto, Junichi, Yamada, Taro, Takata, Yoshimi, Konishi, Kiyoshi, Ogawa, Hirofumi, Gomi, Tomoharu, Fujioka, Motoji, Takusagawa, Fusao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Catalysis Crystallization Crystallography, X-Ray Enzyme Activation - genetics Enzyme Inhibitors - chemistry Enzyme Inhibitors - metabolism Glycine - analogs & derivatives Glycine - chemistry Glycine - metabolism Guanidine - analogs & derivatives Guanidine - chemistry Guanidine - metabolism Guanidinoacetate N-Methyltransferase Methyltransferases - antagonists & inhibitors Methyltransferases - chemistry Methyltransferases - genetics Methyltransferases - metabolism Models, Molecular Mutagenesis, Site-Directed Protein Conformation Rats S-Adenosylhomocysteine - chemistry S-Adenosylhomocysteine - metabolism Substrate Specificity
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