Ligand-Dependent Inhibition and Reversal of Tau Filament Formation

Alzheimer's disease is defined in part by the intraneuronal accumulation of filaments comprised of the microtubule associated protein tau. Because animal model studies suggest that a toxic gain of function accompanies tau aggregation in neurons, selective pharmacological inhibitors of the proce...

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Veröffentlicht in:	Biochemistry (Easton) 2004-03, Vol.43 (10), p.2879-2887
Hauptverfasser:	Chirita, Carmen, Necula, Mihaela, Kuret, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Arachidonic Acid - antagonists & inhibitors Arachidonic Acid - pharmacology Benzothiazoles Carbocyanines - metabolism Carbocyanines - pharmacology Coloring Agents Humans Ligands Microscopy, Electron Microspheres Neurofilament Proteins - antagonists & inhibitors Neurofilament Proteins - metabolism Neurofilament Proteins - ultrastructure Protein Isoforms - antagonists & inhibitors Protein Isoforms - metabolism Protein Isoforms - ultrastructure Protein Processing, Post-Translational - drug effects Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - metabolism Recombinant Proteins - ultrastructure tau Proteins - antagonists & inhibitors tau Proteins - metabolism tau Proteins - ultrastructure Thiazoles - metabolism Thiazoles - pharmacology
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