Motor Domain Mutation Traps Kinesin as a Microtubule Rigor Complex

Conventional kinesin is a highly processive, microtubule-based motor protein that drives the movement of membranous organelles in neurons. Using in vivo genetics in Drosophila melanogaster, Glu164 was identified as an amino acid critical for kinesin function [Brendza, K. M., Rose, D. J., Gilbert, S....

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Veröffentlicht in:	Biochemistry (Easton) 2003-03, Vol.42 (9), p.2595-2606
Hauptverfasser:	Klumpp, Lisa M, Brendza, Katherine M, Rosenberg, John M, Hoenger, Andreas, Gilbert, Susan P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - analogs & derivatives Adenosine Diphosphate - metabolism Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - metabolism Alanine - genetics Animals Binding Sites - genetics Cattle Dimerization Drosophila Proteins - genetics Drosophila Proteins - metabolism Glutamic Acid - genetics Humans Hydrolysis Kinesin - genetics Kinesin - metabolism Kinetics Microtubules - enzymology Microtubules - genetics Molecular Motor Proteins - enzymology Molecular Motor Proteins - genetics Mutagenesis, Site-Directed ortho-Aminobenzoates - metabolism Protein Structure, Tertiary - genetics Rats Static Electricity
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