Repair of Oligodeoxyribonucleotides by O 6-Alkylguanine-DNA Alkyltransferase

Activity of the DNA repair protein O 6-alkylguanine-DNA alkyltransferase (AGT) is an important source of tumor cell resistance to alkylating agents. AGT inhibitors may prove useful in enhancing chemotherapy. AGT is inactivated by reacting stoichiometrically with O 6-benzylguanine (b6G), which is cur...

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Veröffentlicht in:	Biochemistry (Easton) 2002-07, Vol.41 (27), p.8689-8697
Hauptverfasser:	Luu, Kieu X, Kanugula, Sreenivas, Pegg, Anthony E, Pauly, Gary T, Moschel, Robert C
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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