Role of Conserved Transmembrane Cationic Amino Acids in the Prostaglandin Transporter PGT

The prostaglandin transporter “PGT” interacts electrostatically with its anionic substrate, based on inhibition by the disulfonic stilbenes [Chan, B. S. (1998) J. Biol. Chem. 273, 6689−6697], inhibition by the thiol-reactive anion sodium (2-sulfonatoethyl)methanethiosulfonate (MTSES) [Chan, B. S. (1...

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Veröffentlicht in:	Biochemistry (Easton) 2002-07, Vol.41 (29), p.9215-9221
Hauptverfasser:	Chan, Brenda S, Bao, Yi, Schuster, Victor L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acids - physiology Animals Antiporters - chemistry Antiporters - genetics Antiporters - physiology Base Sequence Conserved Sequence DNA Primers DNA-Binding Proteins - chemistry DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology HeLa Cells Humans Indicators and Reagents - chemistry Molecular Sequence Data Mutagenesis, Site-Directed Organic Anion Transporters Rats Sequence Homology, Amino Acid
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