Identification of a Binding Site for Ganglioside on the Receptor Binding Domain of Tetanus Toxin

The carboxyl-terminal region of the tetanus toxin heavy chain (HC fragment) binds to di- and trisialylgangliosides on neuronal cell membranes. To determine which amino acids in tetanus toxin are involved in ganglioside binding, homology modeling was performed using recently resolved X-ray crystallog...

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Veröffentlicht in:	Biochemistry (Easton) 2002-11, Vol.41 (46), p.13644-13652
Hauptverfasser:	Louch, Heather A, Buczko, Ellen S, Woody, Mary A, Venable, Richard M, Vann, Willie F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Circular Dichroism DNA Primers - chemistry Fluorescent Antibody Technique Gangliosides - chemistry Gangliosides - metabolism Histidine - chemistry Kinetics Ligands Liposomes Models, Molecular Mutagenesis, Site-Directed PC12 Cells - cytology Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Polymerase Chain Reaction Rats Receptors, Cell Surface - metabolism Recombinant Proteins - isolation & purification Recombinant Proteins - metabolism Tetanus Toxin - chemistry Tetanus Toxin - genetics Tetanus Toxin - metabolism
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