The Structure of a Mutant Photosynthetic Reaction Center Shows Unexpected Changes in Main Chain Orientations and Quinone Position

We report on the unexpected structural changes caused by substitution of acidic amino acids in the QB binding pocket of the bacterial photosynthetic reaction center by alanines. The mutations targeted key residues L212Glu and L213Asp of this transmembrane protein−cofactor complex. The amino acid sub...

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Veröffentlicht in:	Biochemistry 2002-05, Vol.41 (19), p.5998-6007
Hauptverfasser:	Pokkuluri, P. R, Laible, P. D, Deng, Y.-L, Wong, T. N, Hanson, D. K, Schiffer, M
Format:	Artikel
Sprache:	eng
Schlagworte:	ALANINES Amino Acid Substitution AMINO ACIDS BASIC BIOLOGICAL SCIENCES BENZOQUINONES CHAINS Crystallography, X-Ray GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE Models, Molecular Molecular Structure Mutagenesis, Site-Directed MUTANTS MUTATIONS Photosynthetic Reaction Center Complex Proteins - chemistry Photosynthetic Reaction Center Complex Proteins - genetics PHOTOSYNTHETIC REACTION CENTERS PROTONS Quinones - chemistry RESIDUES Rhodobacter sphaeroides - chemistry Rhodobacter sphaeroides - genetics Static Electricity STRAINS
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