Mammalian DNA Polymerases .alpha., .beta., .gamma., .delta., and .epsilon. Incorporate Fialuridine (FIAU) Monophosphate into DNA and Are Inhibited Competitively by FIAU Triphosphate

Fialuridine [FIAU, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5- iodouridine] was used in clinical trials for chronic hepatitis B virus infection and was extremely toxic. Evidence suggested targets of FIAU toxicity included mitochondria, but toxic mechanisms were unclear. Since FIAU is...

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Veröffentlicht in:	Biochemistry (Easton) 1994-12, Vol.33 (48), p.14620-14624
Hauptverfasser:	Lewis, William, Meyer, Ralph R, Simpson, James F, Colacino, Joseph M, Perrino, Fred W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabinofuranosyluracil - analogs & derivatives Arabinofuranosyluracil - metabolism Arabinofuranosyluracil - pharmacology Binding, Competitive Deoxyuracil Nucleotides - metabolism DNA - biosynthesis DNA-Directed DNA Polymerase - metabolism Kinetics Mammals Mitochondria - metabolism Nucleic Acid Synthesis Inhibitors Substrate Specificity Templates, Genetic Thymine Nucleotides - metabolism
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