Enhanced Potency of Human Sonic Hedgehog by Hydrophobic Modification

Post-translational modifications of the developmental signaling protein Sonic hedgehog (Shh) by a long-chain fatty acid at the N-terminus and cholesterol at the C-terminus greatly activate the protein in a cell-based signaling assay. To investigate the structural determinants of this activation phen...

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Veröffentlicht in:	Biochemistry (Easton) 2001-04, Vol.40 (14), p.4359-4371
Hauptverfasser:	Taylor, Frederick R, Wen, Dingyi, Garber, Ellen A, Carmillo, Amie N, Baker, Darren P, Arduini, Robert M, Williams, Kevin P, Weinreb, Paul H, Rayhorn, Paul, Hronowski, Xiaoping, Whitty, Adrian, Day, Eric S, Boriack-Sjodin, Ann, Shapiro, Renee I, Galdes, Alphonse, Pepinsky, R. Blake
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyl Coenzyme A - chemistry Amides Amino Acid Substitution - genetics Animals Cell Line Circular Dichroism Cysteine - chemistry Cysteine - genetics Ethylmaleimide - chemistry Fatty Acids - chemistry Formaldehyde - chemistry Hedgehog Proteins Humans Indicators and Reagents Intracellular Signaling Peptides and Proteins Iodoacetamide - analogs & derivatives Iodoacetamide - chemistry Membrane Proteins - biosynthesis Membrane Proteins - metabolism Mice Mice, Inbred C3H Patched Receptors Peptide Fragments - chemistry Peptide Fragments - genetics Peptide Fragments - metabolism Protein Binding - genetics Protein Processing, Post-Translational - genetics Proteins - chemistry Proteins - genetics Proteins - metabolism Proteins - physiology Receptors, Cell Surface Signal Transduction - genetics Spectrometry, Mass, Electrospray Ionization Sulfhydryl Compounds - chemistry Thiazoles - chemistry Thiazoles - metabolism Thiazolidines Trans-Activators Up-Regulation - genetics
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