Low- and High-Affinity Phorbol Ester and Diglyceride Interactions with Protein Kinase C:  1-O-Alkyl-2-acyl-sn-glycerol Enhances Phorbol Ester- and Diacylglycerol-Induced Activity but Alone Does Not Induce Activity

Phorbol ester-induced conventional protein kinase C (PKCα, -βΙ/ΙΙ, and -γ) isozyme activities are potentiated by 1,2-diacyl-sn-glycerol. This has been attributed to a “cooperative” interaction of the two activators with two discrete sites termed the low- and high-affinity phorbol ester binding sites...

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