Monoclonal Antibody Conjugates of Doxorubicin Prepared with Branched Linkers:  A Novel Method for Increasing the Potency of Doxorubicin Immunoconjugates

Immunoconjugates of monoclonal antibody BR96 and Doxorubicin have been prepared using a novel series of branched hydrazone linkers. Since each linker bound to the mAb carries two DOX molecules, the DOX/mAb molar ratios of these conjugates were approximately 16, twice that of those previously prepare...

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