Preparation and characterization of a .beta.-lactamase-Fab' conjugate for the site-specific activation of oncolytic agents

Antibody-directed catalysis (ADC) is a two-step method for the targeted delivery of chemotherapeutic agents in which enzyme-antibody conjugates, prelocalized to antigen-bearing cells, activate prodrugs designed to be substrates for the enzyme. An enzyme-Fab' conjugate exhibiting both native bet...

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Veröffentlicht in:	Bioconjugate chemistry 1992-01, Vol.3 (1), p.42-48
Hauptverfasser:	Meyer, Damon L., Jungheim, Louis N., Mikolajczyk, Stephen D., Shepherd, Timothy A., Starling, James J., Ahlem, Clarence N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - metabolism Antineoplastic Agents - toxicity beta-Lactamases - metabolism Biological and medical sciences Carcinoembryonic Antigen - immunology Cephalosporins - administration & dosage Cephalosporins - metabolism Cephalosporins - toxicity Drug Delivery Systems Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology Immunoglobulin Fab Fragments - immunology Prodrugs - administration & dosage Prodrugs - metabolism Tumor Cells, Cultured Vinblastine - administration & dosage Vinblastine - analogs & derivatives Vinblastine - metabolism Vinblastine - toxicity
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