Advances in the Enzymatic Reduction of Ketones
Historically, biocatalytic ketone reductions involved the use of Bakerʼs yeast. Within the last five years, a significant and growing number of isolated ketoreductases have become available that have rendered yeast-based reductions obsolete. The broad substrate range and exquisite selectivities of t...
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| Veröffentlicht in: | Accounts of chemical research 2007-12, Vol.40 (12), p.1412-1419 |
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| container_issue | 12 |
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| container_title | Accounts of chemical research |
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| creator | Moore, Jeffrey C Pollard, David J Kosjek, Birgit Devine, Paul N |
| description | Historically, biocatalytic ketone reductions involved the use of Bakerʼs yeast. Within the last five years, a significant and growing number of isolated ketoreductases have become available that have rendered yeast-based reductions obsolete. The broad substrate range and exquisite selectivities of these enzymes repeatedly outperform other ketone reduction chemistries, making biocatalysis the general method of choice for ketone reductions. Presented here is a summary of our understanding of the capabilities and limitations of these enzymes. |
| doi_str_mv | 10.1021/ar700167a |
| format | Article |
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Chem. Res</addtitle><description>Historically, biocatalytic ketone reductions involved the use of Bakerʼs yeast. Within the last five years, a significant and growing number of isolated ketoreductases have become available that have rendered yeast-based reductions obsolete. The broad substrate range and exquisite selectivities of these enzymes repeatedly outperform other ketone reduction chemistries, making biocatalysis the general method of choice for ketone reductions. 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| ispartof | Accounts of chemical research, 2007-12, Vol.40 (12), p.1412-1419 |
| issn | 0001-4842 1520-4898 |
| language | eng |
| recordid | cdi_crossref_primary_10_1021_ar700167a |
| source | MEDLINE; American Chemical Society Journals |
| subjects | Acetophenones - chemistry Alcohol Oxidoreductases - chemistry Catalysis Coenzymes - chemistry Ketones - chemistry Oxidation-Reduction Stereoisomerism |
| title | Advances in the Enzymatic Reduction of Ketones |
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