Metal Complexes as DNA Intercalators

DNA has a strong affinity for many heterocyclic aromatic dyes, such as acridine and its derivatives. Lerman in 1961 first proposed intercalation as the source of this affinity, and this mode of DNA binding has since attracted considerable research scrutiny. Organic intercalators can inhibit nucleic...

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Veröffentlicht in:	Accounts of chemical research 2011-05, Vol.44 (5), p.349-359
Hauptverfasser:	Liu, Hong-Ke, Sadler, Peter J
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Coordination Complexes - chemistry DNA - chemistry Intercalating Agents - chemistry Magnetic Resonance Spectroscopy Models, Molecular Molecular Structure Osmium - chemistry Ruthenium - chemistry
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