Gold–Oxoborate Nanocomposites and Their Biomedical Applications
A novel inorganic nanocomposite material, called BOA, which has the form of small building blocks composed of gold nanoparticles embedded in a polyoxoborate matrix, is presented. It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward bo...
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| Veröffentlicht in: | ACS applied materials & interfaces 2015-02, Vol.7 (7), p.3931-3939 |
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| container_title | ACS applied materials & interfaces |
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| creator | Wybrańska, Katarzyna Paczesny, Jan Serejko, Katarzyna Sura, Karolina Włodyga, Karolina Dzięcielewski, Igor Jones, Samuel T Śliwa, Agnieszka Wybrańska, Iwona Hołyst, Robert Scherman, Oren A Fiałkowski, Marcin |
| description | A novel inorganic nanocomposite material, called BOA, which has the form of small building blocks composed of gold nanoparticles embedded in a polyoxoborate matrix, is presented. It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward both Gram-positive and -negative bacteria strains. Importantly, the modified cotton does not release any toxic substances, and the bacteria are killed upon contact with the fibers coated with the BOA. Toxicity tests show that the nanocomposite–in spite of its antiseptic properties–is harmless for mammalian cells. The presented method of surface modification utilizes mild, environmentally friendly fabrication conditions. Thus, it offers a facile approach to obtain durable nontoxic antiseptic coatings for biomedical applications. |
| doi_str_mv | 10.1021/am508979y |
| format | Article |
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It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward both Gram-positive and -negative bacteria strains. Importantly, the modified cotton does not release any toxic substances, and the bacteria are killed upon contact with the fibers coated with the BOA. Toxicity tests show that the nanocomposite–in spite of its antiseptic properties–is harmless for mammalian cells. The presented method of surface modification utilizes mild, environmentally friendly fabrication conditions. 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Mater. Interfaces</addtitle><description>A novel inorganic nanocomposite material, called BOA, which has the form of small building blocks composed of gold nanoparticles embedded in a polyoxoborate matrix, is presented. It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward both Gram-positive and -negative bacteria strains. Importantly, the modified cotton does not release any toxic substances, and the bacteria are killed upon contact with the fibers coated with the BOA. Toxicity tests show that the nanocomposite–in spite of its antiseptic properties–is harmless for mammalian cells. The presented method of surface modification utilizes mild, environmentally friendly fabrication conditions. Thus, it offers a facile approach to obtain durable nontoxic antiseptic coatings for biomedical applications.</description><subject>Animals</subject><subject>Anti-Bacterial Agents - chemical synthesis</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Borates - chemistry</subject><subject>Borates - pharmacology</subject><subject>Escherichia coli - drug effects</subject><subject>Gold - chemistry</subject><subject>Gold - pharmacology</subject><subject>Humans</subject><subject>Nanocomposites - chemistry</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Textiles - analysis</subject><subject>Textiles - microbiology</subject><subject>Wool - chemistry</subject><subject>Wool - microbiology</subject><issn>1944-8244</issn><issn>1944-8252</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkLFOwzAYhC0EoqUw8AIoCwNDwL8dJ_YYKihIFV3KHNmOLVIlcWSnEt14B96QJyEokInpbvh0ujuELgHfAiZwJxuGucjE4QjNQSRJzAkjx5NPkhk6C2GHcUoJZqdoRlhKGM34HOUrV5dfH5-bd6ecl72JXmTrtGs6F6rehEi2ZbR9M5WP7ivXmLLSso7yrqsH01euDefoxMo6mItfXaDXx4ft8ileb1bPy3wdSwqsj6nODE-FIlKUFqcWGwGcGYmFAgBlSzCKUpYRwBaUyAyhiZacpiknVmclXaCbMVd7F4I3tuh81Uh_KAAXPzcU0w0DezWy3V4NnSfyb_cAXI-A1KHYub1vh-r_BH0D0CNlIg</recordid><startdate>20150225</startdate><enddate>20150225</enddate><creator>Wybrańska, Katarzyna</creator><creator>Paczesny, Jan</creator><creator>Serejko, Katarzyna</creator><creator>Sura, Karolina</creator><creator>Włodyga, Karolina</creator><creator>Dzięcielewski, Igor</creator><creator>Jones, Samuel T</creator><creator>Śliwa, Agnieszka</creator><creator>Wybrańska, Iwona</creator><creator>Hołyst, Robert</creator><creator>Scherman, Oren A</creator><creator>Fiałkowski, Marcin</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>20150225</creationdate><title>Gold–Oxoborate Nanocomposites and Their Biomedical Applications</title><author>Wybrańska, Katarzyna ; Paczesny, Jan ; Serejko, Katarzyna ; Sura, Karolina ; Włodyga, Karolina ; Dzięcielewski, Igor ; Jones, Samuel T ; Śliwa, Agnieszka ; Wybrańska, Iwona ; Hołyst, Robert ; Scherman, Oren A ; Fiałkowski, Marcin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a315t-3c7e869b2a9df06f0e9185ea09b111bfd1eb3357210f1b97e234ca836682fc7d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Animals</topic><topic>Anti-Bacterial Agents - chemical synthesis</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Borates - chemistry</topic><topic>Borates - pharmacology</topic><topic>Escherichia coli - drug effects</topic><topic>Gold - chemistry</topic><topic>Gold - pharmacology</topic><topic>Humans</topic><topic>Nanocomposites - chemistry</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Textiles - analysis</topic><topic>Textiles - microbiology</topic><topic>Wool - chemistry</topic><topic>Wool - microbiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wybrańska, Katarzyna</creatorcontrib><creatorcontrib>Paczesny, Jan</creatorcontrib><creatorcontrib>Serejko, Katarzyna</creatorcontrib><creatorcontrib>Sura, Karolina</creatorcontrib><creatorcontrib>Włodyga, Karolina</creatorcontrib><creatorcontrib>Dzięcielewski, Igor</creatorcontrib><creatorcontrib>Jones, Samuel T</creatorcontrib><creatorcontrib>Śliwa, Agnieszka</creatorcontrib><creatorcontrib>Wybrańska, Iwona</creatorcontrib><creatorcontrib>Hołyst, Robert</creatorcontrib><creatorcontrib>Scherman, Oren A</creatorcontrib><creatorcontrib>Fiałkowski, Marcin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><jtitle>ACS applied materials & interfaces</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wybrańska, Katarzyna</au><au>Paczesny, Jan</au><au>Serejko, Katarzyna</au><au>Sura, Karolina</au><au>Włodyga, Karolina</au><au>Dzięcielewski, Igor</au><au>Jones, Samuel T</au><au>Śliwa, Agnieszka</au><au>Wybrańska, Iwona</au><au>Hołyst, Robert</au><au>Scherman, Oren A</au><au>Fiałkowski, Marcin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gold–Oxoborate Nanocomposites and Their Biomedical Applications</atitle><jtitle>ACS applied materials & interfaces</jtitle><addtitle>ACS Appl. Mater. Interfaces</addtitle><date>2015-02-25</date><risdate>2015</risdate><volume>7</volume><issue>7</issue><spage>3931</spage><epage>3939</epage><pages>3931-3939</pages><issn>1944-8244</issn><eissn>1944-8252</eissn><abstract>A novel inorganic nanocomposite material, called BOA, which has the form of small building blocks composed of gold nanoparticles embedded in a polyoxoborate matrix, is presented. It is demonstrated that cotton wool decorated with the BOA nanocomposite displays strong antibacterial activity toward both Gram-positive and -negative bacteria strains. Importantly, the modified cotton does not release any toxic substances, and the bacteria are killed upon contact with the fibers coated with the BOA. Toxicity tests show that the nanocomposite–in spite of its antiseptic properties–is harmless for mammalian cells. The presented method of surface modification utilizes mild, environmentally friendly fabrication conditions. Thus, it offers a facile approach to obtain durable nontoxic antiseptic coatings for biomedical applications.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>25625378</pmid><doi>10.1021/am508979y</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Anti-Bacterial Agents - chemical synthesis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Borates - chemistry Borates - pharmacology Escherichia coli - drug effects Gold - chemistry Gold - pharmacology Humans Nanocomposites - chemistry Staphylococcus aureus - drug effects Textiles - analysis Textiles - microbiology Wool - chemistry Wool - microbiology |
| title | Gold–Oxoborate Nanocomposites and Their Biomedical Applications |
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